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. 2012 Sep;101(9):e405-10.
doi: 10.1111/j.1651-2227.2012.02727.x. Epub 2012 May 24.

Human bocavirus types 1, 2 and 3 in acute gastroenteritis of childhood

Minna Risku  1 , Minna Kätkä, Suvi Lappalainen, Sirpa Räsänen, Timo Vesikari
Affiliations

Human bocavirus types 1, 2 and 3 in acute gastroenteritis of childhood

Minna Risku et al. Acta Paediatr. 2012 Sep.

Abstract

Aim: Recently identified human bocavirus (HBoV) types 2 and 3 have been associated with acute gastroenteritis in children. We studied 878 stool specimens from children with acute gastroenteritis and 112 controls (43 children with unspecified fever, 33 with respiratory tract infection and 36 healthy children) for known HBoVs. The same specimens were previously studied for rotaviruses, noroviruses, sapoviruses, adenoviruses, coronaviruses and aichivirus.

Methods: HBoVs were detected by PCR and positive amplicons were sequenced to identify HBoV1, HBoV2, HBoV3 and HBoV4.

Results: HBoV of any type was found in 85 (9.7%) cases of acute gastroenteritis and in 6 (5.4%) controls. HBoV1 was detected in 49 (5.6%) cases and 2 (1.8%) controls, HBoV2 in 29 (3.3%) cases and 2 (1.8%) controls and HBoV3 in 8 (0.9%) cases and 2 (1.8%) controls. No HBoV4 was found. HBoV as a single infection was found in 16 (1.8%) cases and in 6 (5.4%) controls; in the remaining cases, a known gastroenteritis virus was also found. Among the single HBoV infections, HBoV2 was the most common type with 8 (50%) cases.

Conclusion: HBoVs are rarely found alone in children with acute gastroenteritis. Further studies are warranted to confirm a possible specific association of HBoV2 with gastroenteritis.

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Conflict of interest statement

No conflict of interest. No specific funding.

Figures

Figure 1
Figure 1
All human bocavirus (HBoV)‐positive findings and monthly numbers of all tested samples during the study period, August 2006–August 2008. (Notice two vertical scales).
See this image and copyright information in PMC

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