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. 1990 Aug;21(5):867-72.

Endothelin activates the vascular renin-angiotensin system in rat mesenteric arteries

H Rakugi  1 , Y Tabuchi, M Nakamaru, M Nagano, K Higashimori, H Mikami, T Ogihara
Affiliations
  • PMID: 2256949

Endothelin activates the vascular renin-angiotensin system in rat mesenteric arteries

H Rakugi et al. Biochem Int. 1990 Aug.

Abstract

The effects of endothelin on the vascular renin-angiotensin system were examined in isolated perfused rat mesenteric arteries by measuring vascular renin activity and angiotensin II released into the perfusate. Infusion of endothelin (10(-9)M and 10(-11)M) increased the vascular renin activity and angiotensin II release. Pretreatment with nicardipine (10(-6)M), a calcium channel blocker, significantly suppressed these effects of endothelin. These results suggest that endothelin activates the vascular renin-angiotensin system via intracellular calcium metabolism. Vascular angiotensin II produced by endothelin may modulate the local effect of endothelin on the resistance vessels.

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