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. 1990 Dec;62(6):1023-5.
doi: 10.1038/bjc.1990.431.

Phase II trial of UFT in advanced colorectal and gastric cancer

S T Malik  1 , D Talbot, P I Clarke, R Osborne, R Reznek, P F Wrigley, M L Slevin
Affiliations
Free PMC article

Phase II trial of UFT in advanced colorectal and gastric cancer

S T Malik et al. Br J Cancer. 1990 Dec.
Free PMC article

Abstract

A phase II trial of continuous oral therapy with UFT, a combination of uracil and the 5-fluorouracil analogue 1-(2-tetrahydrofuryl)-5-fluorouracil (Futraful, Ftorafur), was conducted in 40 patients with advanced colorectal cancer and 18 patients with advanced gastric cancer. Six partial responses were seen in the 36 evaluable patients with colorectal cancer (response rate 16.6%; 95% confidence limits 6.4-32.8%), and one partial response was seen in the 16 evaluable patients with gastric cancer (response rate 6%; 95% confidence limits 0.27-30.2%). The overall toxicity of the treatment was low, and all patients were treated as outpatients. The results suggest that oral UFT has comparable activity to standard regimes of 5-fluorouracil, and because of the convenience of oral administration is a useful therapy in the management of patients with advanced colorectal cancer.

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