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Review
. 2012 Sep-Oct;20(5):259-63.
doi: 10.1097/CRD.0b013e31825d0a44.

Effects of antihypertensive drugs on arterial stiffness

Tanja Dudenbostel  1 , Stephen P Glasser
Affiliations
Review

Effects of antihypertensive drugs on arterial stiffness

Tanja Dudenbostel et al. Cardiol Rev. 2012 Sep-Oct.

Abstract

In this review, we discuss the possible pathophysiological mechanisms and the role of arterial stiffness as a biomarker, a blood pressure-independent predictor of cardiovascular morbidity and mortality. The effects of different antihypertensive drug classes on noninvasively assessed markers of arterial stiffness are also discussed. Current evidence will be reviewed regarding the effect of drugs on arterial stiffness, including the peripheral and central effects of angiotensin-converting enzyme inhibitors, angiotensin receptor antagonists, dihydropyridine calcium channel blockers, beta blockers (including vasodilating beta blockers), diuretics, and mineralocorticoid antagonists.

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Conflict of interest statement

Disclosure: The authors have no conflict of interest to report.

Figures

Figure 1
Figure 1
The diagram describes the effects of arterial stiffness on the hophysiology of cardiovascular disease. CAF indicates coronary artery flow; CKD, chronic kidney disease; DBP, diastolic blood pressure; HF, heart failure; HFPEF, heart failure with preserved ejection fraction; LEF, left ventricular ejection fraction; LVH, left ventricular hypertrophy; MI, myocardial infarction; PP, pulse pressure; SBP, systolic blood pressure.
See this image and copyright information in PMC

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