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. 2012;7(5):e36576.
doi: 10.1371/journal.pone.0036576. Epub 2012 May 4.

Heart rate-corrected QT interval helps predict mortality after intentional organophosphate poisoning

Shou-Hsuan Liu  1 , Ja-Liang Lin, Cheng-Hao Weng, Huang-Yu Yang, Ching-Wei Hsu, Kuan-Hsing Chen, Wen-Hung Huang, Tzung-Hai Yen
Affiliations

Heart rate-corrected QT interval helps predict mortality after intentional organophosphate poisoning

Shou-Hsuan Liu et al. PLoS One. 2012.

Abstract

Introduction: In this study, we investigated the outcomes for patients with intentional organophosphate poisoning. Previous reports indicate that in contrast to normal heart rate-corrected QT intervals (QTc), QTc prolongation might be indicative of a poor prognosis for patients exposed to organophosphates.

Methods: We analyzed the records of 118 patients who were referred to Chang Gung Memorial Hospital for management of organophosphate poisoning between 2000 and 2011. Patients were grouped according to their initial QTc interval, i.e., normal (<0.44 s) or prolonged (>0.44 s). Demographic, clinical, laboratory, and mortality data were obtained for analysis.

Results: The incidence of hypotension in patients with prolonged QTc intervals was higher than that in the patients with normal QTc intervals (P = 0.019). By the end of the study, 18 of 118 (15.2%) patients had died, including 3 of 75 (4.0%) patients with normal QTc intervals and 15 of 43 (34.9%) patients with prolonged QTc intervals. Using multivariate-Cox-regression analysis, we found that hypotension (OR = 10.930, 95% CI = 2.961-40.345, P = 0.000), respiratory failure (OR = 4.867, 95% CI = 1.062-22.301, P = 0.042), coma (OR = 3.482, 95% CI = 1.184-10.238, P = 0.023), and QTc prolongation (OR = 7.459, 95% CI = 2.053-27.099, P = 0.002) were significant risk factors for mortality. Furthermore, it was revealed that non-survivors not only had longer QTc interval (503.00±41.56 versus 432.71±51.21 ms, P = 0.002), but also suffered higher incidences of hypotension (83.3 versus 12.0%, P = 0.000), shortness of breath (64 versus 94.4%, P = 0.010), bronchorrhea (55 versus 94.4%, P = 0.002), bronchospasm (50.0 versus 94.4%, P = 0.000), respiratory failure (94.4 versus 43.0%, P = 0.000) and coma (66.7 versus 11.0%, P = 0.000) than survivors. Finally, Kaplan-Meier analysis demonstrated that cumulative mortality was higher among patients with prolonged QTc intervals than among those with normal QTc intervals (Log-rank test, Chi-square test = 20.36, P<0.001).

Conclusions: QTc interval helps predict mortality after intentional organophosphate poisoning.

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. Kaplan-Meier analysis of data from patients with organophosphate poisoning, grouped according to the duration of the QTc interval.
Patients with prolonged QTc intervals suffered higher cumulative mortality than patients with normal QTc intervals (Log-rank test, Chi-square test = 20.36, P<0.001).
See this image and copyright information in PMC

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