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Review
. 2013 Feb;65(2):169-90.
doi: 10.1016/j.addr.2012.04.009. Epub 2012 May 7.

Mathematical and pharmacokinetic modelling of epidermal and dermal transport processes

Yuri G Anissimov  1 , Owen G Jepps, Yuri Dancik, Michael S Roberts
Affiliations
Review

Mathematical and pharmacokinetic modelling of epidermal and dermal transport processes

Yuri G Anissimov et al. Adv Drug Deliv Rev. 2013 Feb.

Abstract

Topical delivery to the various regions of the skin and underlying tissues, transdermal drug delivery and dermal exposure to environmental chemicals are important areas of research. Mathematical models of epidermal and dermal transport, involving penetration of a solute through various layers of the skin, metabolism in the skin and its subsequent distribution and clearance into systemic circulation from underlying tissues, play an essential role in this research area and are reviewed in this work.

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