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. 2012 Jul 21;137(14):3227-9.
doi: 10.1039/c2an35138b. Epub 2012 May 11.

Manipulation and capture of Aβ amyloid fibrils and monomers by DC insulator gradient dielectrophoresis (DC-iGDEP)

Sarah J R Staton  1 , Paul V Jones, Ginger Ku, S Douglass Gilman, Indu Kheterpal, Mark A Hayes
Affiliations

Manipulation and capture of Aβ amyloid fibrils and monomers by DC insulator gradient dielectrophoresis (DC-iGDEP)

Sarah J R Staton et al. Analyst. .

Abstract

Here we report a novel method for the manipulation and concentration of Aβ amyloid fibrils, implicated in Alzheimer's disease, using DC insulating gradient dielectrophoresis (DC-iGDEP). Fibril enrichment was found to be ∼400%. Simulations suggest that capture of the full range of amyloid protein aggregates is possible with optimized device design.

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