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Comment
. 2012 Apr;2(4):308-10.
doi: 10.1158/2159-8290.CD-12-0078.

The role of the PGE2-aromatase pathway in obesity-associated breast inflammation

Dingzhi Wang  1 , Raymond N DuBois
Affiliations
Comment

The role of the PGE2-aromatase pathway in obesity-associated breast inflammation

Dingzhi Wang et al. Cancer Discov. 2012 Apr.

Abstract

Subbaramaiah and colleagues present the first evidence indicating that a cyclooxygenase-2-prostaglandin E(2)-aromatase pathway promotes obesity-associated inflammation in women's breast tissues. Their findings shed new light on obesity-associated inflammation in general and provide a rationale for developing effective chemopreventive and therapeutic strategies targeting this pathway for obese women with breast inflammation and patients with hormone-dependent breast cancer.

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