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. 2012:2012:312781.
doi: 10.1155/2012/312781. Epub 2012 Apr 23.

Brain Activity Stimulated by Prism Adaptation Tasks Utilized for the Treatment of Unilateral Spatial Neglect: A Study with fNIRS

Hiroshi Taniguchi  1 , Makoto Hiyamizu, Takanori Tominaga, Shu Morioka
Affiliations

Brain Activity Stimulated by Prism Adaptation Tasks Utilized for the Treatment of Unilateral Spatial Neglect: A Study with fNIRS

Hiroshi Taniguchi et al. Rehabil Res Pract. 2012.

Abstract

We investigated the neurological basis for efficacy of prism adaptation therapy, which is used for the treatment of poststroke unilateral spatial neglect (USN). Study subjects were 6 USN-positive (+), 6 USN-negative patients, and 6 healthy volunteer control subjects. USN was identified by the Behavioural Inattention Test (BIT). During the tasks, brain activity was assessed with fNIRS via changes in oxyHb concentration per unit length. There was no significant difference in the number of errors in the task between the 3 groups. However, in the USN(+) group there was a significantly greater reduction in oxyHb levels in the right parietal association cortex during the prism adaptation task than in the other 2 groups (P < 0.05). There was an immediate improvement in USN symptoms as well as a significant increase in oxyHb levels during the prism adaptation in the channels covering the right frontal and parietal lobes in 2 patients in the USN(+) group (P < 0.05). This result suggested that decreased activity in the right parietal association cortex, which is related to spatial perception, during the prism adaptation task and task-induced reorganization of the right frontal and parietal areas were involved in improvement in USN symptoms.

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Figures

Figure 1
Figure 1
Measurement by functional near infrared spectroscopy. We employed a 49-channel system with 30 optodes. 15 light sources (red numbers) and 15 detectors (blue numbers) that covered the frontoparietal area. Solid white numbers denote measuring channels, which were spread to 8 regions of interest.
Figure 2
Figure 2
Comparison of the number of errors in the prism adaptation task. There was no significant difference between the 3 groups (P = 0.72). USN: unilateral spatial neglect.
Figure 3
Figure 3
Changes in Behavioural Inattention Test (BIT) scores after the prism adaptation task in the USN(+) group. Cases A and B had higher BIT scores that were over the cutoff value (131 points for the ordinary test and 68 points for the action test) after prism adaptation. (128 to 138 points and 68 to 80 points for the ordinary and action tests, resp., in case A; 127 to 132 and 53 to 69 correspondingly in case B). USN: unilateral spatial neglect.
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