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. 2012 Jun;45(6):883-90.
doi: 10.1002/mus.23259.

Neuropathic pain in post-burn hypertrophic scars: a psychophysical and neurophysiological study

Gianluca Isoardo  1 , Maurizio Stella, Dario Cocito, Daniela Risso, Giuseppe Migliaretti, Franco Cauda, Angela Palmitessa, Giuliano Faccani, Palma Ciaramitaro
Affiliations

Neuropathic pain in post-burn hypertrophic scars: a psychophysical and neurophysiological study

Gianluca Isoardo et al. Muscle Nerve. 2012 Jun.

Abstract

Introduction: Pain complicates hypertrophic post-burn pathologic scars (PPS) METHODS: To investigate the possible neuropathic origin of pain, 13 patients with painful PPS involving at least 1 hand underwent clinical examination, including the Douleur Neuropathique en 4 questions (DN4) questionnaire; median, ulnar, and radial nerve conduction studies (NCS); cold- (CDT) and heat-induced pain threshold evaluation by quantitative sensory testing; and cutaneous silent period (CSP) testing of the abductor pollicis brevis. Controls included 9 patients with non-painful PPS, 52 healthy subjects, and 28 patients with carpal tunnel syndrome (CTS).

Results: All patients with painful PPS had possible neuropathic pain (DN4 score ≥4). NCS signs of CTS were similarly present in PPS subjects with or without pain. Hands with painful PPS had lower CDT and CSP duration, more frequent cold- and heat-pain hypesthesia, and more thermal allodynia than controls.

Conclusions: In PPS, possible neuropathic pain is associated with psychophysical and neurophysiological abnormalities suggestive of small-fiber damage.

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