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. 2012 Jun 1;14(11):2874-7.
doi: 10.1021/ol301104n. Epub 2012 May 14.

Ruthenium(II)-catalyzed synthesis of hydroxylated arenes with ester as an effective directing group

Yiqing Yang  1 , Yun Lin, Yu Rao
Affiliations

Ruthenium(II)-catalyzed synthesis of hydroxylated arenes with ester as an effective directing group

Yiqing Yang et al. Org Lett. .

Abstract

An unprecedented Ru(II) catalyzed ortho-hydroxylation has been developed for the facile synthesis of a variety of multifunctionalized arenes from easily accessible ethyl benzoates with ester as an efficient directing group. Both the TFA/TFAA cosolvent system and oxidants serve as the critical success factors in this transformation. The reaction demonstrates excellent reactivity, good functional group tolerance, and high yields.

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