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. 2012 Aug;79(2):189-92.
doi: 10.1016/j.mehy.2012.04.031. Epub 2012 May 12.

How metabolic acidosis and oxidative stress alone and interacting may increase the risk of fracture in diabetic subjects

L A Frassetto  1 , A Sebastian
Affiliations

How metabolic acidosis and oxidative stress alone and interacting may increase the risk of fracture in diabetic subjects

L A Frassetto et al. Med Hypotheses. 2012 Aug.

Abstract

Subjects with either type 1 or type 2 diabetes are at higher risk for having fractures, a risk not necessarily improved by better glucose control. In this article, we argue that low grade metabolic acidosis and increased oxidative stress occurring in bone disease in part as a result of complications of diabetes, reinforce each other, and together constitute a double jeopardy for the development of bone fractures in diabetic subjects.

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