Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2012 Jun;132(6):1535-8.
doi: 10.1038/jid.2012.134.

Capturing the finer points of gene expression in psoriasis: beaming in on the CCL19/CCR7 axis

Laure Rittié  1 , James T Elder
Affiliations
Comment

Capturing the finer points of gene expression in psoriasis: beaming in on the CCL19/CCR7 axis

Laure Rittié et al. J Invest Dermatol. 2012 Jun.

Abstract

Laser capture microdissection-coupled complementary DNA microarray analysis is a powerful tool for studying minor cell populations in tissues. In this issue, Mitsui et al. use this method to characterize the immune infiltrates that localize in the dermis of psoriatic skin. They identify the T-cell activation regulators C-C chemokine ligand 19 and C-C chemokine receptor 7 as potential mediators of immune organization in psoriasis.

PubMed Disclaimer

Conflict of interest statement

CONFLICT OF INTEREST

The authors state no conflict of interest.

Comment on

References

    1. Capon F, Burden DA, Trembath RC, et al. Psoriasis and other complex trait dermatoses: from loci to functional pathways. J Invest Dermatol. 2012;132:915–22. - PMC - PubMed
    1. Chiricozzi A, Guttman-Yassky E, Suarez-Farinas M, et al. Integrative responses to IL-17 and TNF-alpha in human keratinocytes account for key inflammatory pathogenic circuits in psoriasis. J Invest Dermatol. 2011;131:677–87. - PubMed
    1. Elder JT, Bruce AT, Gudjonsson JE, et al. Molecular dissection of psoriasis: integrating genetics and biology. J Invest Dermatol. 2010;130:1213–26. - PubMed
    1. Emmert-Buck MR, Bonner RF, Smith PD, et al. Laser capture microdissection. Science. 1996;274:998–1001. - PubMed
    1. Isenberg G, Bielser W, Meier-Ruge W, et al. Cell surgery by laser micro-dissection: a preparative method. J Microsc. 1976;107:19–24. - PubMed

Publication types

MeSH terms