Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2012 Jun;132(6):1538-41.
doi: 10.1038/jid.2012.77.

Stem cells in tissue repair and regeneration

Vincent Falanga  1
Affiliations
Comment

Stem cells in tissue repair and regeneration

Vincent Falanga. J Invest Dermatol. 2012 Jun.

Abstract

The field of tissue repair and wound healing has blossomed in the past 30 years. We have gone from recombinant growth factors, to living tissue engineering constructs, to stem cells. The task now is to pursue true regeneration, thus achieving complete restoration of structure and function.

PubMed Disclaimer

Figures

Figure 1
Figure 1
The left side of the figure shows a non-healing chronic wound due to a combination of venous and lymphatic disease. Both arrows point to the non-migrating epidermis. The solid arrow shows the steep edges at the periphery of the wound, while the dashed arrow is directed at an island of fully epithelialized tissue within the wound bed, but with continued failure of its epidermis to migrate. The right side of the figure is a diagrammatic representation of the different phases of wound healing which, in the case of chronic wounds, are not linear or predictable in their sequence. Also, different areas of the wound are likely to be in a different phase of wound healing. The dashed lines in the diagram point to the fact that this is a dynamic situation and, thus, not easily predictable.
See this image and copyright information in PMC

Comment on

References

    1. Danner The use of human sweat gland-derived stem cells for enhancing vascularization during dermal regeneration. J Invest Dermatol In Press. - PubMed
    1. Falanga V. Classifications for wound bed preparation and stimulation of chronic wounds. Wound Repair Regen. 2000;8:347–52. - PubMed
    1. Falanga V. Wound healing and its impairment in the diabetic foot. Lancet. 2005;366:1736–43. - PubMed
    1. Falanga V, Iwamoto S, Chartier M, Yufit T, Butmarc J, Kouttab N, et al. Autologous bone marrow-derived cultured mesenchymal stem cells delivered in a fibrin spray accelerate healing in murine and human cutaneous wounds. Tissue Eng. 2007;13:1299–312. - PubMed
    1. Falanga V, Sabolinski M. A bilayered living skin construct (APLIGRAF) accelerates complete closure of hard-to-heal venous ulcers. Wound Repair Regen. 1999;7:201–7. - PubMed

Publication types