Calcium balance in chronic kidney disease: walking the tightrope
- PMID: 22584593
- DOI: 10.1038/ki.2012.33
Calcium balance in chronic kidney disease: walking the tightrope
Abstract
Calcium supplements for prevention and treatment of mineral and bone disorders in chronic kidney disease (CKD) have been alternately praised and damned. Clinical evidence in favor of either attitude has been lacking. The calcium balance study by Spiegel and Brady in patients with late stage 3 and stage 4 CKD suggests that CKD subjects ingesting 2000 mg of elemental calcium per day are in marked positive balance. Methodological limitations such as unproven steady state warrant caution and confirmatory studies.
Comment on
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Calcium balance in normal individuals and in patients with chronic kidney disease on low- and high-calcium diets.Kidney Int. 2012 Jun;81(11):1116-22. doi: 10.1038/ki.2011.490. Epub 2012 Feb 1. Kidney Int. 2012. PMID: 22297674 Free PMC article. Clinical Trial.
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