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Comment
. 2012 Feb;2(2):115-6.
doi: 10.1158/2159-8290.CD-11-0356.

New roles opined for OPCML

Sherry Y Wu  1 , Anil K Sood
Affiliations
Comment

New roles opined for OPCML

Sherry Y Wu et al. Cancer Discov. 2012 Feb.

Abstract

OPCML, frequently inactivated in ovarian tumors, mediates its antitumor effect via binding to the extracellular domains of several important oncogenic receptor tyrosine kinases (RTK). This, in turn, leads to the downregulation of RTKs in tumor cells and results in significant inhibition of tumor growth.

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Figures

Figure 1
Figure 1
Schematic illustration of the mechanism by which rOPCML mediates its anti-tumor effect in OPCML-negative cells.
See this image and copyright information in PMC

Comment on

References

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