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Comment
. 2011 Jul;1(2):106-7.
doi: 10.1158/2159-8290.CD-11-0116.

New routes to old places: PIK3R1 and PIK3R2 join PIK3CA and PTEN as endometrial cancer genes

Sandra Herrero-Gonzalez  1 , Antonio Di Cristofano
Affiliations
Comment

New routes to old places: PIK3R1 and PIK3R2 join PIK3CA and PTEN as endometrial cancer genes

Sandra Herrero-Gonzalez et al. Cancer Discov. 2011 Jul.

Abstract

Cheung and colleagues identify PIK3R1 and PIK3R2, the genes encoding the α and β isoforms of the phosphatidylinositol 3-kinase (PI3K) p85 regulatory subunit, as additional mutation targets in endometrial cancer, and describe a novel mechanism leading to PTEN loss.

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