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Comment
. 2011 Nov;1(6):466-8.
doi: 10.1158/2159-8290.CD-11-0259.

Understanding the lethal variant of prostate cancer: power of examining extremes

Ana Aparicio  1 , Christopher J Logothetis, Sankar N Maity
Affiliations
Comment

Understanding the lethal variant of prostate cancer: power of examining extremes

Ana Aparicio et al. Cancer Discov. 2011 Nov.

Abstract

Small cell prostate carcinoma is a lethal variant of castration-resistant prostate cancer. Beltran and colleagues identified overexpression and amplification of both aurora kinase A (AURKA) and the MYCN proto-oncogene in the small cell prostate carcinomas and propose Aurora kinase A as a potential therapeutic target in this disease subset.

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Figures

Figure 1
Figure 1
Upper panel. Neuroendocrine Prostate Cancer (NEPC) biology is estimated to drive approximately 25% of lethal prostate cancers. Lower panel. Mitotic and neural development pathways have been implicated in the progression to androgen-independent NEPC and offer targets that might change the course of the disease. NEPC is often found mixed with AR-positive adenocarcinoma elements. An understanding of the role of adaptive AR signaling present in association with NEPC is also needed.
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References

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