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. 2012 Jun 1;14(11):2870-3.
doi: 10.1021/ol301113v. Epub 2012 May 15.

Copper-mediated oxidative cross-coupling reaction of terminal alkynes with α-silyldifluoromethylphosphonates: an efficient method for α,α-difluoropropargylphosphonates

Xueliang Jiang  1 , Lingling Chu, Feng-Ling Qing
Affiliations

Copper-mediated oxidative cross-coupling reaction of terminal alkynes with α-silyldifluoromethylphosphonates: an efficient method for α,α-difluoropropargylphosphonates

Xueliang Jiang et al. Org Lett. .

Abstract

A copper-mediated oxidative cross-coupling reaction of terminal alkynes with readily available α-silyldifluoromethylphosphonates under mild conditions has been developed. This method allows for an efficient synthesis of a series of synthetically useful α,α-difluoropropargylphosphonates with excellent functional group compatibility.

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