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Meta-Analysis
. 2012 Mar 21:1:21.
doi: 10.1186/2046-4053-1-21.

Antenatal magnesium individual participant data international collaboration: assessing the benefits for babies using the best level of evidence (AMICABLE)

AMICABLE Group  1
Collaborators, Affiliations
Meta-Analysis

Antenatal magnesium individual participant data international collaboration: assessing the benefits for babies using the best level of evidence (AMICABLE)

AMICABLE Group. Syst Rev. .

Abstract

Background: The primary aim of this study is to assess, using individual participant data (IPD) meta-analysis, the effects of administration of antenatal magnesium sulphate given to women at risk of preterm birth on important clinical outcomes for their child such as death and neurosensory disability. The secondary aim is to determine whether treatment effects differ depending on important pre-specified participant and treatment characteristics, such as reasons at risk of preterm birth, gestational age, or type, dose and mode of administration of magnesium sulphate.

Design: The Antenatal Magnesium Individual Participant Data (IPD) International Collaboration: assessing the benefits for babies using the best level of evidence (AMICABLE) Group will perform an IPD meta-analysis to answer these important clinical questions. SETTING/TIMELINE: The AMICABLE Group was formed in 2009 with data collection commencing late 2010.

Inclusion criteria: Five trials involving a total 6,145 babies are eligible for inclusion in the IPD meta-analysis. PRIMARY STUDY OUTCOMES: For the infants/children: Death or cerebral palsy. For the women: Any severe maternal outcome potentially related to treatment (death, respiratory arrest or cardiac arrest).

Discussion: Results are expected to be publicly available in 2012.

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References

    1. Doyle LW, Victorian Infant Collaborative S. Outcome at 5 years of age of children 23 to 27 weeks' gestation: Refining the prognosis. Pediatrics. 2001;108(1):134–141. doi: 10.1542/peds.108.1.134. - DOI - PubMed
    1. Saigal S, Doyle LW. An overview of mortality and sequelae of preterm birth from infancy to adulthood. Lancet. 2008;371(9608):261–269. doi: 10.1016/S0140-6736(08)60136-1. - DOI - PubMed
    1. Martin JA, Hamilton BE, Sutton PD, Ventura SJ, Menacker F, Kirmeyer S, Munson ML. Births: final data for 2005. Natl Vital Stat Rep. 2007;56(6):1–103. - PubMed
    1. Laws P, Li Z, Sullivan EA. Australia's mothers and babies 2008, Perinatal statistics series no. 24. Cat. no. PER 50. Canberra: AIHW; 2010.
    1. Oxford Register of Early Childhood Impairment. National Perinatal Epidemiology Unit 2001 Annual Report. Oxford: Institue of Health Sciences; 2001.

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