Sidestream microstream end tidal carbon dioxide measurements and blood gas correlations in neonatal intensive care unit

Abstract

Objective: The study was designed to assess the use of newer sidestream microstream end tidal carbon dioxide (ETCO(2) ) device in predicting blood carbon dioxide (PCO(2) ) measurements in very low birth weight (VLBW = birth weight <1,500 g) and non-VLBW NICU neonates.

Study design: Sidestream microstream ETCO(2) detectors were allowed time to calibrate and reach steady state prior to blood gas measurements. Blood CO(2) (PCO(2) ) and simultaneous ETCO(2) were recorded. Ratio of dead space to tidal volume (VD/VT) was calculated using modified Bohr's equation. Correlation coefficient, estimates of difference, standard deviation, and 95% limits of agreement between ETCO(2) and PCO(2) concentrations were calculated.

Results: Two hundred eighty-six paired samples were collected from 48 ventilated NICU patients. Average PCO(2) and ETCO(2) were 58.4 and 50.6 with a correlation of 0.76. Subgroup analysis showed a correlation of 0.73 in 204 paired blood from 34 VLBW infants and 0.82 in 82 paired samples from non-VLBW infants. Estimates of difference ± standard deviation between PCO(2) and ETCO(2) concentrations in these three groups, respectively (ALL, VLBW, and non-VLBW) were 7.84 ± 9.96, 8.2 ± 10.16, and 6.95 ± 9.45. The correlation coefficient significantly improved in the VLBW group to 0.86 with dead space to tidal volume ratio (VD/VT) <30% (0.86 vs. 0.42; P < 0.001).

Conclusion: ETCO(2) measurements using sidestream microstream technology in VLBW demonstrated that the correlation of ETCO(2) and PCO(2) was moderate, but the agreement was less than adequate (bias > 5 mmHg in all groups). The results improved with lower VD/VT, suggesting that sidestream capnography is more reliable in conditions of less severe lung disease.