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. 2012 Jun 25;51(26):6488-92.
doi: 10.1002/anie.201201921. Epub 2012 May 15.

Catalytic C-H amination with aromatic amines

Raymond T Gephart 3rd  1 , Daria L Huang, Mae Joanne B Aguila, Graham Schmidt, Andi Shahu, Timothy H Warren
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Catalytic C-H amination with aromatic amines

Raymond T Gephart 3rd et al. Angew Chem Int Ed Engl. .

Abstract

Aniline joins the club: A β-diketiminato copper(I) catalyst enables C-H amination of anilines employing low catalyst loadings to preclude oxidation to the diazene ArN=NAr. Electron-poor anilines are particularly resistant towards diazene formation and participate in the amination of strong and unactivated C-H bonds. N-alkyl anilines also take part in C-H amination.

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