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Case Reports
. 2010 Aug;5(4):246-249.
doi: 10.1159/000313982. Epub 2010 Aug 9.

Myoepithelial Carcinoma: A Rare Neoplasm of the Breast

Kuo-Chun Liao  1 , Wen-Ying Lee, Ming-Jenn Chen
Affiliations
Case Reports

Myoepithelial Carcinoma: A Rare Neoplasm of the Breast

Kuo-Chun Liao et al. Breast Care (Basel). 2010 Aug.

Abstract
in English, German

BACKGROUND: Malignant myoepitheliomas of the breast are extremely rare. There has been a limited number of published reports of myoepithelial carcinomas originating from the breast. CASE REPORT: We describe a malignant myoepithelioma of the breast in a 56-year-old woman. Histological examination showed polygonal epithelioid cells and spindle cells with moderate to marked nuclear atypia. Immunohistochemistry showed reactivity in the spindle cells for smooth muscle actin, cytokeratin (AE1/AE3), and p63, indicating a myoepithelial cell lineage of tumor cells. The patient underwent radical surgical excision of the lesion and axillary lymph node dissection. She demonstrated no evidence of recurrence over an 11-month follow-up. CONCLUSIONS: We suggest myoepithelial carcinomas of the breast be managed with appropriate surgical clearance. A multidisciplinary approach is usually required.

Hintergrund: Maligne Myoepitheliome der Brust sind extrem selten. Es existiert nur eine begrenzte Anzahl an Berichten über aus dem Brustgewebe stammende myoepitheliale Karzinome

Fallbericht: Wir beschreiben den Fall eines malignen Myoepithelioms der Brust bei einer 56-jährigen Patientin. Die histologische Untersuchung zeigte polygonale epitheloide Zellen und Spindelzellen mit moderater bis starker Kernatypie. Die immunhisto-chemische Untersuchung ergab Reaktivität in den Spindelzellen auf Glattmuskel-Aktin, Zytokeratin (AE1/AE3) und p63, was auf eine myoepitheliale Abstammung der Tumorzellen hindeutet. Eine radikale chirugische Resektion des Tumors und Exstirpation der Achsellymphknoten wurden durchgeführt. Während eines 11-monatigen Follow-ups zeigte die Patientin keine Anzeichen eines Rückfalls

Schlussfolgerungen: Wir schlagen bei myoepithelialen Karzinomen der Brust eine angemessene chirurgische Resektion vor. Ein multidisziplinärer Ansatz ist in der Regel erforderlich.

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Figures

Fig. 1
Fig. 1
A Mammogram of the left breast showing regional architectural distortion without microcalcification at the lower inner quadrant. B Sonography showing a slightly hypoechoic mass with irregular margins.
Fig. 2
Fig. 2
A Hematoxylin and Eosin stained section of the lesion showing a spindle cell neoplasm with marked nuclear atypia and frequent mitoses ×400) B Section of the lesion immunostained for p63 showing strong reactivity in the tumor cells (×400).
See this image and copyright information in PMC

References

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