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. 2012 Apr 28;4(4):174-8.
doi: 10.4329/wjr.v4.i4.174.

ARFI elastography for the evaluation of diffuse thyroid gland pathology: Preliminary results

Ioan Sporea  1 , Roxana Sirli, Simona Bota, Mihaela Vlad, Alina Popescu, Ioana Zosin
Affiliations

ARFI elastography for the evaluation of diffuse thyroid gland pathology: Preliminary results

Ioan Sporea et al. World J Radiol. .

Abstract

Aim: To assess whether acoustic radiation force impulse (ARFI) elastography can differentiate normal from pathological thyroid parenchyma.

Methods: We evaluated 136 subjects (mean age 45.8 ± 15.6 years, 106 women and 30 men): 44 (32.3%) without thyroid pathology, 48 (35.3%) with Basedow-Graves' disease (GD), 37 (27.2%) with chronic autoimmune thyroiditis (CAT; diagnosed by specific tests), 4 (2.9%) with diffuse thyroid goiter and 3 (2.2%) cases with thyroid pathology induced by amiodarone. In all patients, 10 elastographic measurements were made in the right thyroid lobe and 10 in the left thyroid lobe, using a 1-4.5 MHZ convex probe and a 4-9 MHz linear probe, respectively. Median values were calculated for thyroid stiffness and expressed in meters/second (m/s).

Results: Thyroid stiffness (TS) assessed by means of ARFI in healthy subjects (2 ± 0.40 m/s) was significantly lower than in GD (2.67 ± 0.53 m/s) (P < 0.0001) and CAT patients (2.43 ± 0.58 m/s) (P = 0.0002), but the differences were not significant between GD vs CAT patients (P = 0.053). The optimal cut-off value for the prediction of diffuse thyroid pathology was 2.36 m/s. For this cut-off value, TS had 62.5% sensitivity, 79.5% specificity, 87.6% predictive positive value, 55.5% negative predictive value and 72.7% accuracy for the presence of diffuse thyroid gland pathology (AUROC = 0.804). There were no significant differences between the TS values obtained with linear vs convex probes and when 5 vs 10 measurements were taken in each lobe (median values).

Conclusion: ARFI seems to be a useful method for the assessment of diffuse thyroid gland pathology.

Keywords: Acoustic radiation force impulse elastography; Thyroid pathology; Thyroid stiffness.

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Figures

Figure 1
Figure 1
Acoustic radiation force impulse measurement in the left thyroid lobe (with convex probe).
Figure 2
Figure 2
Mean thyroid stiffness values assessed by acoustic radiation force impulse elastography in healthy subjects vs patients with thyroid pathology. GD: Graves’ disease; CAT: Chronic autoimmune thyroiditis.
Figure 3
Figure 3
Mean thyroid stiffness values according to thyroid stimulating hormone levels. TSH: thyroid stimulating hormone.
See this image and copyright information in PMC

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