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. 2012 Feb;32(188):98-102.

[Assess the impact of concentrations of inflammatory markers IL-6, CRP in the presence of albuminuria in patients with type 2 diabetes]

[Article in Polish]
Jolanta Czyzewska  1 , Katarzyna Wasilewska, Joanna Kamińska, Olga Koper, Halina Kemona, Iwona Jakubowska
Affiliations
  • PMID: 22590912

[Assess the impact of concentrations of inflammatory markers IL-6, CRP in the presence of albuminuria in patients with type 2 diabetes]

[Article in Polish]
Jolanta Czyzewska et al. Pol Merkur Lekarski. 2012 Feb.

Abstract

Diabetic nephropathy is one of the most common complications of diabetes. Symptom of nephropathy is albuminuria, in which the mechanism of formation may participates CRP and IL-6. The aim of the study was to evaluate the concentrations of CRP and IL-6 depending on the irregularity of metabolic patients with type 2 diabetes and their impact on the occurrence of albuminuria.

Material and methods: The study was conducted among 68 patients with type 2 diabetes with albuminuria. Patients were divided into groups: group I - patients with type 2 diabetes with HbA1c > or = 6.1 - < or = 6.5%, group II - patients with type 2 diabetes with HbA1c > 6.5 - < or = 10.0%, K - control group, 21 patients with essential hypertension with albuminuria. The material was consisted of venal extracted for clot drawn from the basilic vain. IL 6 concentration was assessed using the ELISA method. The percentage of hemoglobin A1c (HbA1c), CRP, the extent of albuminuria was determined by immunoturbidimetric method.

Results: The mean urinary albumin excretion was highest in the second study group, lowerin the test group, the lowest in the control group. The average concentration of IL-6 and CRP was highest in group I, lower in group II, the lowest in the control group (p > 0.05). It has been shown a positive correlation between serum CRP and the magnitude of albuminuria in the test group of patients with type 2 diabetes with HbA1c > or = 6.1 - < or = 6.5% (p < 0.037). The relationship between serum CRP and the magnitude of albuminuria in the control group of patients with essential hypertension were at the border of statistical significance (p < 0.057). Not shown a positive correlation between these parameters in the second group of patients with type 2 diabetes with HbA1c >6.5 - < or = 10.0%.

Conclusions: In patients with type 2 diabetes with better metabolic control, protein CRP is a sensitive marker of albuminuria.

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