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. 2012 Jun 6;134(22):9406-9.
doi: 10.1021/ja302641e. Epub 2012 May 29.

Hole transfer in LNA and 5-Me-2'-deoxyzebularine-modified DNA

Kiyohiko Kawai  1 , Mitsuo Hayashi, Tetsuro Majima
Affiliations

Hole transfer in LNA and 5-Me-2'-deoxyzebularine-modified DNA

Kiyohiko Kawai et al. J Am Chem Soc. .

Abstract

We report the measurement of hole-transfer rate constants (k(ht)) in locked nucleic acid (LNA) and 5-Me-2'-deoxyzebularine (B)-modified DNA. LNA modification, which makes DNA more rigid, caused a decrease of more than 2 orders of magnitude in k(ht), whereas B modification, which increases DNA flexibility, increased k(ht) by more than 20-fold. The present results clearly showed that hole-transfer efficiency in DNA can be increased by increasing DNA flexibility.

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