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Review
. 2012 May 1;5(3):392-9.
doi: 10.1161/CIRCIMAGING.112.973727.

Molecular imaging of aortic aneurysms

Denis B Buxton  1
Affiliations
Review

Molecular imaging of aortic aneurysms

Denis B Buxton. Circ Cardiovasc Imaging. .
No abstract available

PubMed Disclaimer

Figures

Figure 1
Figure 1
A: Typical images of stage II, III, and IV abdominal aortic aneurysms (AAAs) obtained after CNA-35 injection at day 5 and day 15 of AAA development. Corresponding histological sections stained with combined Masson elastin are shown in the third column. B: Quantification of aneurysm severity (increasing from stage I to IV) and normalized signal enhancement percentage (%NSE) relative to CNA-35 injection. From Klink et al with permission from Elsevier.
Figure 2
Figure 2
Graded increase in MMPs within the aneurysmal lesions in fibulin-4+/R and fibulin-4R/R mice ex vivo. B, Quantification of FMT-derived fluorescence of excited fluorochrome in the aorta. C, Ex vivo analysis of the MMP increase within the aortic arch area in fibulin-4+/+ and fibulin-4+/R mice. D, Isosurface concentration mapping from reconstructed tomographic images showing a graded increase in activation of signal within the aortic arch area of fibulin-4+/R and fibulin-4R/R mice compared to wild-type fibulin-4+/+ animals E, Three-dimensional FMT-CT co-registration of the heart and aorta of a heterozygous fibulin-4+/R mouse. From Kaijzel et al with permission from Wolters Kluwer Health
Figure 3
Figure 3
Imaging in mice with early-stage aneurysms undergoing 7 days of Ang-II administration. A, PET signals from aneurysms and from wild-type mice. B, Representative PET-CT images of a nascent AA. * indicates liver signal. C, Flow cytometric analysis of leukocytes in the aorta of wild-type mice (left 2 plots) and apoE−/− mice (right 2 plots) after 7 days of Ang-II administration. The gated regions in the left plots for each mouse type depict the monocyte/macrophage population, which were further analyzed for expression of the monocyte surface marker Ly6-C and the macrophage marker F4/80 (plots on the right). Lin indicates lineage antigens (CD90/B220/CD49b/NK1.1/Ly-6G). Numbers contained within the gated regions of the plots (left plots) indicate the percentage of living cells (macrophages/monocytes). Numbers in the quadrants (right plots) indicate the percentage of monocytes/macrophages in each gate. D, Serial CT angiography after PET-CT on day 7 in Ang-II treated apoE−/− mice. Left panel shows the diameter of aneurysms with low PET signal; right panel shows diameter of aneurysms with high signal. From Nahrendorf et al with permission from Wolters Kluwer Health
Figure 4
Figure 4
Top: Color maps (A through C) showing representative abdominal aortic aneurysm (AAA) slices from patients in each of the 3 groups alongside the corresponding T2W anatomic images (D through F). The color scale represents the magnitude of the change in T2* value, with blue indicating minimal change and red indicating a large change in T2* value. A distinctive pattern is seen for each patient group: A, Group 1 shows a large change in T2* value only in the periluminal area; B, Group 2, diffuse patchy changes in T2* throughout the intraluminal thrombus but no distinct focal area of USPIO uptake affecting the aortic wall; and C, Group 3, discrete focal area of USPIO uptake involving the wall of the AAA that is distinct from the periluminal region. This patient subsequently died suddenly from presumed ruptured AAA. Bottom: Relationship of diameter and growth rate with patient group. Initial aneurysm diameters (open bars) are similar for the 3 groups, but the aneurysm growth rates (solid bars) are higher for patients in group 3 (0.66 cm/y) compared with those in groups 1 (0.22cm/y) and 2 (0.24 cm/y). From Richards et al with permission from Wolters Kluwer Health.
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