Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2012 May 22;109(21):7955-6.
doi: 10.1073/pnas.1205457109. Epub 2012 May 16.

Tumor suppressor p53 (TP53) at the crossroads of the exposome and the cancer genome

Aaron J Schetter  1 , Curtis C Harris
Affiliations
Comment

Tumor suppressor p53 (TP53) at the crossroads of the exposome and the cancer genome

Aaron J Schetter et al. Proc Natl Acad Sci U S A. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1.
Fig. 1.
Analysis of the exposome (external and internal environment) and the cancer genome (somatic and germ-line mutations and epigenetic changes, e.g., DNA methylation and noncoding RNAs) will improve the understanding carcinogenesis, cancer therapy, and cancer prevention.
See this image and copyright information in PMC

Comment on

  • Aristolochic acid-associated urothelial cancer in Taiwan.
    Chen CH, Dickman KG, Moriya M, Zavadil J, Sidorenko VS, Edwards KL, Gnatenko DV, Wu L, Turesky RJ, Wu XR, Pu YS, Grollman AP. Chen CH, et al. Proc Natl Acad Sci U S A. 2012 May 22;109(21):8241-6. doi: 10.1073/pnas.1119920109. Epub 2012 Apr 9. Proc Natl Acad Sci U S A. 2012. PMID: 22493262 Free PMC article.

References

    1. Nigro JM, et al. Mutations in the p53 gene occur in diverse human tumour types. Nature. 1989;342:705–708. - PubMed
    1. Hollstein M, Sidransky D, Vogelstein B, Harris CC. p53 mutations in human cancers. Science. 1991;253:49–53. - PubMed
    1. Stransky N, et al. The mutational landscape of head and neck squamous cell carcinoma. Science. 2011;333:1157–1160. - PMC - PubMed
    1. Cancer Genome Atlas Research Network Integrated genomic analyses of ovarian carcinoma. Nature. 2011;474:609–615. - PMC - PubMed
    1. Chen C-H, et al. Aristolochic acid-associated urothelial cancer in Taiwan. Proc Natl Acad Sci USA. 2012;109:8241–8246. - PMC - PubMed

Publication types

MeSH terms