Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2012 May;13(7):751-6.
doi: 10.2217/pgs.12.46.

Program in pharmacogenomics at the Ohio State University Medical Center

Joseph P Kitzmiller, Peter J Embi, Kandamurugu Manickam, Kevin M Sweet, Mitch A Phelps, Rebecca D Jackson, Clay B Marsh, Wolfgang Sadee

Program in pharmacogenomics at the Ohio State University Medical Center

Joseph P Kitzmiller et al. Pharmacogenomics. 2012 May.

Abstract

Established in 2002, the Ohio State University Medical Center Program in Pharmacogenomics, lead by Wolfgang Sadee, is comprised of nearly 50 members dedicated to the discovery, investigation and translation of genetic biomarkers with the primary goal of advancing personalized healthcare. This article describes the research teams, bioinformatics infrastructure, supporting laboratories and Centers for Personalized Healthcare and for Clinical and Translational Science, current molecular genetic studies, translational and clinical pharmacogenomic studies, examples of biomarkers under development, and the future directions of the program.

PubMed Disclaimer

Conflict of interest statement

Financial & competing interests disclosure

The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.

References

    1. Hudson KL. Genomics, health care, and society. N. Engl. J. Med. 2011;365(11):1033–1041. - PubMed
    1. Wang D, Guo Y, Wrighton SA, Cooke GE, Sadee W. Intronic polymorphism in CYP3A4 affects hepatic expression and response to statin drugs. Pharmacogenomics J. 2011;11(4):274–286. - PMC - PubMed
    1. Elens L, van Schaik RH, Panin N, et al. Effect of a new functional CYP3A4 polymorphism on a calcineurin inhibitors’ dose requirements and trough blood levels in stable renal transplant patients. Pharmacogenomics. 2011;12(10):1383–1396. - PubMed
    1. Elens L, Bouamar R, Hesselink DA, et al. The new CYP3A4 intron 6 C>T polymorphism (CYP3A4*22) is associated with an increased risk of delayed graft function and worse renal function in cyclosporine-treated kidney transplant patients. Pharmacogenet. Genomics. 2012 (Epub ahead of print). - PubMed
    1. Elens L, Bouamar R, Hesselink DA, et al. A new functional CYP3A4 intron 6 polymorphism significantly affects tacrolimus pharmacokinetics in kidney transplant recipients. Clin. Chem. 2011;57(11):1574–1583. - PubMed

Publication types