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Review
. 2012 Jun;9(2):170-9.
doi: 10.1016/j.pdpdt.2011.10.001. Epub 2011 Nov 1.

mTHPC--a drug on its way from second to third generation photosensitizer?

Mathias O Senge  1
Affiliations
Review

mTHPC--a drug on its way from second to third generation photosensitizer?

Mathias O Senge. Photodiagnosis Photodyn Ther. 2012 Jun.

Abstract

5,10,15,20-Tetrakis(3-hydroxyphenyl)chlorin (mTHPC, Temoporfin) is a widely investigated second generation photosensitizer. Its initial use in solution form (Foscan®) is now complemented by nanoformulations (Fospeg®, Foslip®) and new chemical derivatives related to the basic hydroxyphenylporphyrin framework. Advances in formulation, chemical modifications and targeting strategies open the way for third generation photosensitizers and give an illustrative example for the developmental process of new photoactive drugs.

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