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. 1977 Nov;29(11):684-7.
doi: 10.1111/j.2042-7158.1977.tb11435.x.

Estimation of the degree of crystallinity in digoxin by X-ray and infrared methods

D B Black, E G Lovering

Estimation of the degree of crystallinity in digoxin by X-ray and infrared methods

D B Black et al. J Pharm Pharmacol. 1977 Nov.

Abstract

The X-ray procedure for estimation of the degree of crystallinity in digoxin is based upon measurement of the total X-ray scattering and the scattering from crystalline regions of the drug. The infrared procedures are based upon measurement of the peak height ratios, 1775/1618 and 3095/1618 cm-1. Correlation between results obtained by the two methods is good. These methods are of value in the physico-chemical characterization of digoxin, particularly as the properties may be altered by comminution.

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