doi: 10.1007/BF00455236.
Isolation of an aminoglycoside receptor from guinea pig inner ear tissues and kidney
- PMID: 226045
- DOI: 10.1007/BF00455236
Item in Clipboard
Isolation of an aminoglycoside receptor from guinea pig inner ear tissues and kidney
Arch Otorhinolaryngol.
1979.
Free article
Abstract
Affinity chromatography was used to isolate aminoglycoside receptors from inner ear tissues and kidney. Neomycin was immobilized on glass beads and served as the stationary phase in column chromatography. Fractionation of an organic tissue extract on this matrix demonstrated two components with high affinity for neomycin: phohphatidyl inositol phosphate and phosphatidyl inositol diphosphate. The toxicity of aminoglycosides is explained on the basis of a drug-interaction with these lipids.
Similar articles
-
Assay of aminoglycosides is influenced by tissue homogenization technique.Experientia. 1981 Dec 15;37(12):1357-8. doi: 10.1007/BF01948411. Experientia. 1981. PMID: 7327257 No abstract available.
-
Purification of polyphosphoinositides by chromatography on immobilized neomycin.J Lipid Res. 1978 Nov;19(8):1063-7. J Lipid Res. 1978. PMID: 215685
-
Effects of neomycin on polyphosphoinositides in inner ear tissues and monomolecular films.Adv Exp Med Biol. 1977;84:191-208. doi: 10.1007/978-1-4684-3279-4_9. Adv Exp Med Biol. 1977. PMID: 197827
-
Molecular mechanisms of drug-induced hearing loss.Hear Res. 1986;22:297-304. doi: 10.1016/0378-5955(86)90105-x. Hear Res. 1986. PMID: 3015857 Review.
-
Inner ear test battery in guinea pig models - a review.Acta Otolaryngol. 2018 Jun;138(6):519-529. doi: 10.1080/00016489.2017.1419576. Epub 2018 Jan 8. Acta Otolaryngol. 2018. PMID: 29310507 Review.
Cited by
-
Protective effect of piperacillin against nephrotoxicity of cephaloridine and gentamicin in animals.Antimicrob Agents Chemother. 1988 Jun;32(6):912-8. doi: 10.1128/AAC.32.6.912. Antimicrob Agents Chemother. 1988. PMID: 3415211 Free PMC article.
-
Immunocytochemical detection of triphosphoinositide in vestibular hair cells.Histochemistry. 1985;82(2):197-9. doi: 10.1007/BF00708205. Histochemistry. 1985. PMID: 2987162
-
Drug-induced ototoxicity. Pathogenesis and prevention.Med Toxicol Adverse Drug Exp. 1989 Nov-Dec;4(6):452-67. doi: 10.1007/BF03259926. Med Toxicol Adverse Drug Exp. 1989. PMID: 2689838 Review.
-
Localization of an aminoglycoside (streptomycin) in the inner ear after its systemic administration. A histochemical study using fluorescence microscopy.Histochemistry. 1986;84(3):237-40. doi: 10.1007/BF00495788. Histochemistry. 1986. PMID: 3011710
-
Localization of triphosphoinositide in the cochlea. An electronmicroscopic immunocytochemical study.Histochemistry. 1984;81(2):157-60. doi: 10.1007/BF00490110. Histochemistry. 1984. PMID: 6208171
References
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
