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. 2012 Mar;37(3):149-61.

Roflumilast (daliresp): a novel phosphodiesterase-4 inhibitor for the treatment of severe chronic obstructive pulmonary disease

Roflumilast (daliresp): a novel phosphodiesterase-4 inhibitor for the treatment of severe chronic obstructive pulmonary disease

Jordan Baye. P T. 2012 Mar.
No abstract available

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Figures

Figure 1
Figure 1
Chemical structure of roflumilast. (From Daliresp prescribing information.11)
Figure 2
Figure 2
Effect of concomitant drugs on the exposure of roflumilast and roflumilast N-oxide. Dashed lines indicate the lower and higher bounds (0.8–1.25) of the 90% confidence interval (CI) of the geometric mean ratio of Cmax or area-under-the-curve (AUC) concentration for roflumilast or roflumilast N-oxide for treatment (roflumilast + coadministered drug) vs. reference (roflumilast). (From Daliresp prescribing information.11)

References

    1. Celli BR, MacNee W. Standards for the diagnosis and treatment of patients with COPD: A summary of the ATS/ERS [American Thoracic Society/European Respiratory Society] position paper. Eur Respir J. 2004;23(6):932–946. - PubMed
    1. Williams DM, Bourdet SV. Chronic obstructive pulmonary disease. In: DiPiro JT, Talbert RL, Yee GC, et al., editors. Pharmacotherapy: A Pathophysiologic Approach. 7th ed. New York: McGraw-Hill Medical; p. 2008.
    1. Hill AT, Bayley D, Stockley RA. The interrelationship of sputum inflammatory markers in patients with chronic bronchitis. Am J Respir Crit Care Med. 1999;160(3):893–898. - PubMed
    1. Global Initiative for Chronic Obstructive Lung Disease Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Pulmonary Disease. (Updated 2011). Available at: www.gold-copd.org/uploads/users/files/gold_Re-port_2011_Jan21.pdf. Accessed February 2, 2012. - PubMed
    1. Mannino DM, Gagnon RC, Petty TL, Lydick E. Obstructive lung disease and low lung function in adults in the United States: Data from the National Health and Nutrition Examination Survey, 1988–1994. Arch Intern Med. 2000;160(11):1683–1689. - PubMed

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