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Review
. 2012;13(4):5179-5194.
doi: 10.3390/ijms13045179. Epub 2012 Apr 24.

Filamentous bacteriophage fd as an antigen delivery system in vaccination

Antonella Prisco  1 , Piergiuseppe De Berardinis  2
Affiliations
Review

Filamentous bacteriophage fd as an antigen delivery system in vaccination

Antonella Prisco et al. Int J Mol Sci. 2012.

Abstract

Peptides displayed on the surface of filamentous bacteriophage fd are able to induce humoral as well as cell-mediated immune responses, which makes phage particles an attractive antigen delivery system to design new vaccines. The immune response induced by phage-displayed peptides can be enhanced by targeting phage particles to the professional antigen presenting cells, utilizing a single-chain antibody fragment that binds dendritic cell receptor DEC-205. Here, we review recent advances in the use of filamentous phage fd as a platform for peptide vaccines, with a special focus on the use of phage fd as an antigen delivery platform for peptide vaccines in Alzheimer's Disease and cancer.

Keywords: antigen delivery system; bacteriophage fd; vaccine.

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Figures

Figure 1
Figure 1
The structure of wild type page fd, and engineered phages. Hybrid phages based on vector fdAMPLAY88 display antigen on recombinant pVIII proteins, interspersed with wild type pVIII. fdAMPLAY388 vector allows the display of anti-DEC-205 on pIII protein. Double hybrid phages generated with fdAMPLAY88 and pTfd8SHU display two different antigens on the same virion.
See this image and copyright information in PMC

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