Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Randomized Controlled Trial
. 2012:2012:810234.
doi: 10.1100/2012/810234. Epub 2012 Apr 19.

A randomized comparative trial on the therapeutic efficacy of topical aloe vera and Calendula officinalis on diaper dermatitis in children

Yunes Panahi  1 , Mohamad Reza Sharif, Alireza Sharif, Fatemeh Beiraghdar, Zahra Zahiri, Golnoush Amirchoopani, Eisa Tahmasbpour Marzony, Amirhossein Sahebkar
Affiliations
Randomized Controlled Trial

A randomized comparative trial on the therapeutic efficacy of topical aloe vera and Calendula officinalis on diaper dermatitis in children

Yunes Panahi et al. ScientificWorldJournal. 2012.

Abstract

Introduction: Diaper dermatitis (DD) is a common inflammatory disorder among children and infants. The objective of the present randomized and double-blind trial was to compare the therapeutic efficacies of aloe vera cream and Calendula officinalis ointment on the frequency and severity of DD in children.

Methods: Sixty-six infants with DD (aged < 3 years) were randomized to receive either aloe cream (n = 32) or Calendula ointment (n = 34). Infants were treated with these drugs 3 times a day for 10 days. The severity of dermatitis was graded at baseline as well as at the end of trial using a 5-point scale. The adverse effects of study medications were assessed during the trial.

Results: Although improvement in the severity of DD was observed in both treatment groups (P < 0.001), patients receiving Calendula ointment had significantly fewer rash sites compared to aloe group (P = 0.001). No adverse effect was reported from either of the medications.

Discussion: The evidence from this study suggests that topical aloe and in particular Calendula could serve as safe and effective treatment for the treatment of diaper dermatitis in infants.

PubMed Disclaimer

References

    1. Friedlander SF, Eichenfield LF, Leyden J, Shu J, Spellman MC. Diaper dermatitis: appropriate evaluation and optimal management strategies. Medisys Health Communications, pp. 1–16, 2009.
    1. Atherton DJ. A review of the pathophysiology prevention and treatment of irritant diaper dermatitis. Current Medical Research and Opinion. 2004;20(5):645–649. - PubMed
    1. Adam R. Skin care of the diaper area. Pediatric Dermatology. 2008;25(4):427–433. - PubMed
    1. Berg RW. Etiologic factors in diaper dermatitis: a model for development of improved diapers. Pediatrician. 1987;14(1):27–33. - PubMed
    1. Leyden JJ. Diaper dermatitis. Dermatologic Clinics. 1986;4(1):23–28. - PubMed

Publication types

MeSH terms