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. 2012 Jan 9;51(2):394-8.
doi: 10.1002/anie.201105079.

A chiral phenoxyamine magnesium catalyst for the enantioselective hydroamination/cyclization of aminoalkenes and intermolecular hydroamination of vinyl arenes

Xiaoming Zhang  1 , Thomas J Emge, Kai C Hultzsch
Affiliations

A chiral phenoxyamine magnesium catalyst for the enantioselective hydroamination/cyclization of aminoalkenes and intermolecular hydroamination of vinyl arenes

Xiaoming Zhang et al. Angew Chem Int Ed Engl. .

Abstract

If Grignard had only known! A chiral magnesium complex catalyzes the intramolecular hydroamination/cyclization of aminoalkenes with high efficiency at temperatures as low as −20 °C and enantioselectivities as high as 93 % ee. The high activity of this system also allows the catalytic intermolecular anti-Markovnikov addition of pyrrolidine and benzylamine to vinyl arenes.

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