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Review
. 2012 Sep;48(9):325-30.
doi: 10.1016/j.arbres.2012.04.011. Epub 2012 May 17.

Role of MicroRNAs in lung disease

[Article in English, Spanish]
Martín Angulo  1 , Emilia Lecuona, Jacob Iasha Sznajder
Affiliations
Review

Role of MicroRNAs in lung disease

[Article in English, Spanish]
Martín Angulo et al. Arch Bronconeumol. 2012 Sep.

Abstract

MicroRNAs (miRNAs) are small non-coding RNA molecules that negatively regulate gene expression. They actively participate in the modulation of important cell physiological processes and are involved in the pathogenesis of lung diseases such as lung cancer, pulmonary fibrosis, asthma and chronic obstructive pulmonary disease. A better understanding of the role that miRNAs play in these diseases could lead to the development of new diagnostic and therapeutic tools. In this review, we discuss the role of some miRNAs in different lung diseases as well as the possible future of these discoveries in clinical applications.

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Figures

Fig. 1
Fig. 1
Schematic representation of the different stages in the biogenesis of miRs and repression mechanisms of gene expression: mRNA degradation or inhibition of its translation. Also shown are the possible secretions of miRs, as well as their interaction with non-coding, long-chain RNA.
See this image and copyright information in PMC

References

    1. Nana-Sinkam SP, Hunter MG, Nuovo GJ, Schmittgen TD, Gelinas R, Galas D, et al. Integrating the MicroRNome into the study of lung disease. Am J Respir Crit Care Med. 2009;179:4–10. - PMC - PubMed
    1. Tomankova T, Petrek M, Kriegova E. Involvement of microRNAs in physiological and pathological processes in the lung. Respir Res. 2010;11:159. - PMC - PubMed
    1. Zhou T, Garcia JG, Zhang W. Integrating microRNAs into a system biology approach to acute lung injury. Transl Res. 2011;157:180–90. - PMC - PubMed
    1. Oglesby IK, McElvaney NG, Greene CM. MicroRNAs in inflammatory lung disease—master regulators or target practice? Respir Res. 2010;11:148. - PMC - PubMed
    1. Sayed D, Abdellatif M. MicroRNAs in development and disease. Physiol Rev. 2011;91:827–87. - PubMed

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