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Multicenter Study
. 2012 Sep;27(8 Suppl):32-6.
doi: 10.1016/j.arth.2012.03.020. Epub 2012 May 17.

Are metal ion levels a useful trigger for surgical intervention?

William L Griffin  1 , Thomas K Fehring, James C Kudrna, Robert H Schmidt, Michael J Christie, Susan M Odum, Anne C Dennos
Affiliations
Multicenter Study

Are metal ion levels a useful trigger for surgical intervention?

William L Griffin et al. J Arthroplasty. 2012 Sep.

Abstract

The purpose of this study was to determine if cobalt and chromium ion levels can predict soft tissue damage at total hip revision. This study included 90 metal-on-metal total hip patients with preoperative cobalt and chromium ion levels. Tissue damage noted at revision surgery was graded on a 4-point scale. Sensitivity, specificity, and predictive values were calculated for various threshold values. Receiver operating characteristic analysis was conducted. Using 7 ppb as a threshold, cobalt and chromium ion levels had poor sensitivity and specificity (Co, 65% and 56%; Cr, 29% and 75%). Positive predictive values for cobalt and chromium were only 48% and 26% respectively. The area under the curve was 0.37 for cobalt and 0.44 for chromium. The length of time to revision significantly correlated with tissue damage (P = .001). Ion levels are unreliable predictors of periarticular soft tissue damage and should not be used in isolation as surgical intervention triggers.

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