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. 2012 May 18;17(5):5952-71.
doi: 10.3390/molecules17055952.

Antibacterial evaluation of some Schiff bases derived from 2-acetylpyridine and their metal complexes

Nura Suleiman Gwaram  1 , Hapipah Mohd Ali, Hamid Khaledi, Mahmood Ameen Abdulla, A Hamid A Hadi, Thong Kwai Lin, Chai Lay Ching, Cher Lin Ooi
Affiliations

Antibacterial evaluation of some Schiff bases derived from 2-acetylpyridine and their metal complexes

Nura Suleiman Gwaram et al. Molecules. .

Abstract

A series of Schiff bases derived from 2-acetylpyridne and their metal complexes were characterized by elemental analysis, NMR, FT-IR and UV-Vis spectral studies. The complexes were screened for anti-bacterial activity against Methicillin-resistant Staphylococcus aureus (MRSA), Acinetobacter baumanni (AC), Klebsiella pneumonie (KB) and Pseudomonas aeruginosa (PA) using the disc diffusion and micro broth dilution assays. Based on the overall results, the complexes showed the highest activities against MRSA while a weak antibacterial activity was observed against A. baumanii and P. aeruginosa.

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Figures

Scheme 1
Scheme 1
Reaction pathway for the coordinated complexes.
Figure 1
Figure 1
The molecular X-ray structure of 8 and 9 showing the atom labeling scheme (50% probability ellipsoids). Hydrogen atoms are drawn as spheres of arbitrary radius.
Figure 2
Figure 2
Histogram for the 10 MRSA clinical strains of Schiff-base complexes.
Figure 3
Figure 3
Photograph showing the antibacterial (MRSA 0804-25-A,B,C) and (MRSA 0807-7-a,b,c) screening.
See this image and copyright information in PMC

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