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Editorial
. 2012 Jun;40(6):1970-2.
doi: 10.1097/CCM.0b013e31824e1a1f.

Fluid balance and outcome in acute kidney injury: is fluid really the best medicine?

Editorial

Fluid balance and outcome in acute kidney injury: is fluid really the best medicine?

Raghavan Murugan et al. Crit Care Med. 2012 Jun.
No abstract available

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Figures

Figure 1
Figure 1. Conceptual model illustrating relationship between time, volume of fluid, and potential complications
The model depicts a curvilinear association between time, volume of fluid, and morbidity. Insufficient volume of fluid early during illness is likely to lead to complications due to organ ischemia. In contrast, late administration of excess fluid after onset of organ dysfunction could potentiate organ edema. Optimal volume of fluid at any given time is likely to preserve organ viability without increasing morbidity.

Comment on

References

    1. Bouchard J, Soroko SB, Chertow GM, Himmelfarb J, Ikizler TA, Paganini EP, Mehta RL. Fluid accumulation, survival and recovery of kidney function in critically ill patients with acute kidney injury. Kidney Int. 2009;76:422–427. - PubMed
    1. Payen D, de Pont AC, Sakr Y, Spies C, Reinhart K, Vincent JL. A positive fluid balance is associated with a worse outcome in patients with acute renal failure. Crit Care. 2008;12:R74. - PMC - PubMed
    1. Fulop T, Pathak MB, Schmidt DW, Lengvarszky Z, Juncos JP, Lebrun CJ, Brar H, Juncos LA. Volume-related weight gain and subsequent mortality in acute renal failure patients treated with continuous renal replacement therapy. ASAIO J. 2012;56:333–337. - PMC - PubMed
    1. Grams ME, Estrella MM, Coresh J, Brower RG, Liu KD. Fluid balance, diuretic use, and mortality in acute kidney injury. Clin.J.Am.Soc.Nephrol. 2011;6:966–973. - PMC - PubMed
    1. Rivers E, Nguyen B, Havstad S, Ressler J, Muzzin A, Knoblich B, Peterson E, Tomlanovich M. Early goal-directed therapy in the treatment of severe sepsis and septic shock. N.Engl.J.Med. 2001;345:1368–1377. - PubMed