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. 1990 Nov;9(9):691-6.
doi: 10.1089/dna.1990.9.691.

Simultaneous synthesis of multiple oligonucleotides using nucleoside-H-phosphonate intermediates

H Seliger  1 , R Rösch
Affiliations

Simultaneous synthesis of multiple oligonucleotides using nucleoside-H-phosphonate intermediates

H Seliger et al. DNA Cell Biol. 1990 Nov.

Abstract

A semimechanized simultaneous synthesis of multiple oligonucleotides using nucleoside-H-phosphonates as intermediates was developed and applied to the preparation of hybridization probes. The synthesis could be done with equivalent results (about 98% average yield per cycle) using regenerated H-phosphonates.

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