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. 1990 Oct;4(10):995-9.
doi: 10.1097/00002030-199010000-00008.

Immunological changes in primary HIV-1 infection

H Gaines  1 , M A von Sydow, L V von Stedingk, G Biberfeld, B Böttiger, L O Hansson, P Lundbergh, A B Sönnerborg, J Wasserman, O O Strannegåard
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Immunological changes in primary HIV-1 infection

H Gaines et al. AIDS. 1990 Oct.

Abstract

Homosexual men with symptomatic primary HIV-1 infection displayed a pronounced lymphopaenia with significantly depressed numbers of CD3+, CD4+ and CD8+ cells and B cells during the first week of illness. Subsequently, the CD8+ cell counts rose in parallel with numbers of CD3+ cells, atypical lymphocytes and activated (CD38+ and HLA-Dr+) cells to attain maximal levels about a month following onset of illness. In contrast CD4+ and B cell numbers remained low for an extended period of time. Early signs of a host response included a transient appearance of interferon-alpha in the blood and raised levels of neopterin and beta 2-microglobulin (beta 2-M). Neither CD4+/CD8+ cell ratio nor beta 2-M resumed completely normal values during a follow-up period of 2 years. These findings shed some light on pathogenetic events during early HIV-1 infection and suggest that the infection, following the acute symptomatic stage, usually enters a stage of chronic active rather than latent infection.

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