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. 2011 Aug 1;1(1):9.
doi: 10.1186/2045-3329-1-9. Epub 2011 Aug 1.

Vaginal metastasis of a Ewing Sarcoma five years after resection of the primary tumor

Noemie Vanel, Victoire Vierling, Jennifer Kreshak, Marco Gambarotti, Stefania Cocchi, Cristina Tranfaglia, Daniel Vanel

Vaginal metastasis of a Ewing Sarcoma five years after resection of the primary tumor

Noemie Vanel et al. Clin Sarcoma Res. .

Abstract

A 35-year-old female presented with pain and swelling of the left wrist. A diagnosis of Ewing sarcoma was made and she underwent neoadjuvant chemotherapy and surgery. Macroscopic viable areas remained on the map of the surgical specimen; as such, she was classified as a poor responder and received high dose adjuvant chemotherapy. She remained disease-free for five years, until age 40. A vaginal polyp was then detected during a routine gynaecologic examination. It was removed and histopathology revealed metastatic Ewing sarcoma. To our knowledge, this is the first reported case of a vaginal metastasis of Ewing sarcoma.

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Figures

Figure 1
Figure 1
Initial evaluation. CT: lytic lesion with partial cortical destruction.
Figure 2
Figure 2
Axial T1W MR image after contrast medium injection: the soft tissue extension is well studied.
Figure 3
Figure 3
Sagital T1W MR image, after contrast medium injection. Medullary and soft tissue extensions are well evaluated.
Figure 4
Figure 4
The metastasis is made of homogeneous small round cells.
Figure 5
Figure 5
Interphase FISH with the EWSR1 (22q12) break-apart probe. Within a single nucleus fused red/green signals mark one intact 22q12 region, whereas split red/green signals indicate the presence of an EWSR1 gene rearrangement.
See this image and copyright information in PMC

References

    1. Dahin's Bone Tumors. Lippincott. 6. Vol. 18. p. 249.
    1. Bacci G, Ferrari S, Rosito P, Avella M, Barbieri E, Picci P, Battistini A, Brach del Prever A. Minerva Pediatr. Ewing's sarcoma of the bone. Anatomoclinical study of 424 cases. 1992;44(7-8):345–59. - PubMed
    1. Zoubek A, Kovar H, Gadner H. Cytogenetic and molecular genetic changes in malignant primary bone tumors] Radiologe. 1998. pp. 467–71. - PubMed
    1. Picci P, Böhling T, Bacci G, Ferrari S, Sangiorgi L, Mercuri M, Ruggieri P, Manfrini M, Ferraro A, Casadei R, Benassi MS, Mancini AF, Rosito P, Cazzola A, Barbieri E, Tienghi A, Brach del Prever A, Comandone A, Bacchini P, Bertoni F. Chemotherapy-induced tumor necrosis as a prognostic factor in localized Ewing's sarcoma of the extremities. J Clin Oncol. 1997;15(4):1553–9. - PubMed
    1. Ferrari S, Sundby Hall K, Luksch R, Tienghi A, Wiebe T, Fagioli F, Alvegard TA, Brach Del Prever A, Tamburini A, Alberghini M, Gandola L, Mercuri M, Capanna R, Mapelli S, Prete A, Carli M, Picci P, Barbieri E, Bacci G, Smeland S. Nonmetastatic Ewing family tumors: high-dose chemotherapy with stem cell rescue in poor responder patients. Results of the Italian Sarcoma Group/Scandinavian Sarcoma Group III protocol. Ann Oncol. 2010. in press . - PubMed

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