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Review
. 2013 May;65(5):663-76.
doi: 10.1016/j.addr.2012.05.004. Epub 2012 May 18.

Therapeutic platforms based on gold nanoparticles and their covalent conjugates with drug molecules

Leonid Vigderman  1 , Eugene R Zubarev
Affiliations
Review

Therapeutic platforms based on gold nanoparticles and their covalent conjugates with drug molecules

Leonid Vigderman et al. Adv Drug Deliv Rev. 2013 May.

Abstract

This review will first look at the various covalent strategies that have been developed to attach drugs to gold nanoparticles as well as the strengths and limitations of such strategies. After examining general strategies for the synthesis of gold nanoparticles and their subsequent covalent functionalization, this review will focus on nanoparticle conjugates for gene therapy, antibacterial, and anticancer applications including the use of gold nanoparticles with intrinsically therapeutic properties. The effects of targeting and cellular uptake of gold nanoparticles will also be discussed.

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