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Review
. 2012 Aug;14(10):831-7.
doi: 10.1016/j.micinf.2012.04.011. Epub 2012 May 3.

The role of cGMP signalling in regulating life cycle progression of Plasmodium

Christine S Hopp  1 , Paul W Bowyer, David A Baker
Affiliations
Review

The role of cGMP signalling in regulating life cycle progression of Plasmodium

Christine S Hopp et al. Microbes Infect. 2012 Aug.

Abstract

The 3'-5'-cyclic guanosine monophosphate (cGMP)-dependent protein kinase (PKG) is the main mediator of cGMP signalling in the malaria parasite. This article reviews the role of PKG in Plasmodium falciparum during gametogenesis and blood stage schizont rupture, as well as the role of the Plasmodium berghei orthologue in ookinete differentiation and motility, and liver stage schizont development. The current views on potential effector proteins downstream of PKG and the mechanisms that may regulate cyclic nucleotide levels are presented.

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