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Review
. 2012 May;94(4):e152-4.
doi: 10.1308/003588412X13171221589135.

Urinary tract transitional cell carcinoma and melanosis of the bladder: a case report and review of the literature

J A Harikrishnan  1 , S Chilka, S Jain
Affiliations
Review

Urinary tract transitional cell carcinoma and melanosis of the bladder: a case report and review of the literature

J A Harikrishnan et al. Ann R Coll Surg Engl. 2012 May.

Abstract

Melanosis vesica is a rare condition and thought to be benign. We report the case of a 50-year-old man who presented with haematuria and was found to have a diffusely pigmented bladder on cystoscopy and high grade transitional cell carcinoma of his upper and lower renal tract. This required a laparoscopic nephroureterectomy and pathology confirmed a diagnosis of melanosis vesica. Melanosis vesica has only been associated with high grade transitional cell carcinoma in one previous case. We recommend that any patient presenting with bladder melanosis is monitored for the development of upper or lower urinary tract transitional cell carcinoma.

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Figures

Figure 1
Figure 1
Melanin deposits seen in the bladder at cystoscopy
Figure 2
Figure 2
Melanin deposits seen in the bladder during open surgery
Figure 3
Figure 3
Haematoxylin and eosin stain (40x magnification): The melanin deposits appear dark brown on staining.
Figure 4
Figure 4
Schmorl’s stain (40x magnification): The melanin deposits appear blue-green on staining.
See this image and copyright information in PMC

References

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