Contribution of IL12A and IL12B polymorphisms to the risk of cervical cancer

Abstract

We studied the contribution of the IL12A 3'UTR G>A (rs568408) and IL12B 3'UTR A>C (rs3212227) polymorphisms to the risk of cervical cancer. These polymorphisms were genotyped in four hundred-five patients with cervical cancer and four hundred fifty unrelated healthy females from the Polish population. Logistic regression analysis adjusting for age, pregnancy, oral contraceptive use, tobacco smoking, and menopausal status revealed that the IL12B 3'UTR A>C polymorphism could be a genetic risk factor for cervical cancer. The adjusted odds ratio (OR) for patients with the A/C genotype vs A/A genotype was 1.557 (95 % CI = 1.173-2.066, p = 0.0178) and adjusted OR for the C/C or A/C genotype vs the A/A genotype was 1.635 (95 % CI = 1.241-2.153, p = 0.0125). However, logistic regression analysis did not show an association of the IL12A 3'UTR G>A polymorphism with cervical cancer development in the studied Polish population. Our studies confirmed that the IL12B 3'UTR A>C polymorphism may be a genetic risk factor for cervical cancer.