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Comment
. 2012 Jun 5;109(23):8797-8.
doi: 10.1073/pnas.1206736109. Epub 2012 May 21.

Packaging of influenza virus genome: robustness of selection

Takeshi Noda  1 , Yoshihiro Kawaoka
Affiliations
Comment

Packaging of influenza virus genome: robustness of selection

Takeshi Noda et al. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1.
Fig. 1.
(A) Conflicting hypothetical models of the genome packaging mechanism. Replication of the viral genome takes place in the nucleus of the virus-infected cell. The viral RNA segments, in the form of RNPs, are transported to the plasma membrane, where the segmented genome is packaged, and progeny virions are produced. a, The selective packaging model, highlighted by Chou et al. (2), proposes that eight unique viral RNA segments are consistently packaged into every progeny virus particle. b. In the random packaging model, viral RNA segments are arbitrarily packaged into virus particles, and only a small proportion of the progeny virus particles are infectious. (B) EM analysis shows that the eight RNPs are arranged in a distinct pattern when packaged in a virus particle (11). (C) A 3D model of the eight RNPs within a virus particle reconstructed by using ET (13). The RNPs differ in length and are labeled with different colors.
See this image and copyright information in PMC

Comment on

References

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    1. Chou Y-y, et al. One influenza virus particle packages eight unique viral RNAs as shown by FISH analysis. Proc Natl Acad Sci USA. 2012;109:9101–9106. - PMC - PubMed
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