Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2012 Jun 5;109(23):8795-6.
doi: 10.1073/pnas.1206730109. Epub 2012 May 21.

Dual functions of adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 (APPL1) in insulin signaling and insulin secretion

Weiping Han  1
Affiliations
Comment

Dual functions of adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 (APPL1) in insulin signaling and insulin secretion

Weiping Han. Proc Natl Acad Sci U S A. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

The author declares no conflict of interest.

Figures

Fig. 1.
Fig. 1.
Cross-talk between insulin secretion and insulin signaling. Multiple components of insulin secretion are under the regulation of metabolic and neurohormonal signaling, including insulin signaling. APPL1 is involved in the direct regulation of insulin secretion, possibly by up-regulating the expression of SNARE proteins. GLUT2, glucose transporter 2; S25, SNAP-25; syb, synaptobrevin; synt, syntaxin; Syt7, synaptotagmin-7; TCA, tricarboxylic acid cycle; TRB3, tribble-3.
See this image and copyright information in PMC

Comment on

References

    1. Gustavsson N, et al. Impaired insulin secretion and glucose intolerance in synaptotagmin-7 null mutant mice. Proc Natl Acad Sci USA. 2008;105:3992–3997. - PMC - PubMed
    1. Gustavsson N, Han W. Calcium-sensing beyond neurotransmitters: Functions of synaptotagmins in neuroendocrine and endocrine secretion. Biosci Rep. 2009;29:245–259. - PubMed
    1. Taniguchi CM, Emanuelli B, Kahn CR. Critical nodes in signalling pathways: Insights into insulin action. Nat Rev Mol Cell Biol. 2006;7:85–96. - PubMed
    1. Gerber SH, Südhof TC. Molecular determinants of regulated exocytosis. Diabetes. 2002;51(Suppl 1):S3–S11. - PubMed
    1. Cheng KKY, et al. APPL1 potentiates insulin secretion in pancreatic β cells by enhancing protein kinase Akt-dependent expression of SNARE proteins in mice. Proc Natl Acad Sci USA. 2012;109:8919–8924. - PMC - PubMed

Publication types

MeSH terms

LinkOut - more resources