Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2012 May 23;32(21):7106-8.
doi: 10.1523/JNEUROSCI.1133-12.2012.

Correlated voltage dependences of ion channels revealed

Albert W Hamood  1 , Marie L Goeritz
Affiliations
Comment

Correlated voltage dependences of ion channels revealed

Albert W Hamood et al. J Neurosci. .
No abstract available

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
Covariation of voltage dependences tunes rebound firing. A, Although voltage-dependent current properties vary across the population of neurons, shown here schematically for the voltage of IA half-inactivation (V1/2_inact) and IH half-activation (V1/2_act), analysis in individual cells reveals a correlation. In neurons with a relatively hyperpolarized voltage of IA inactivation (low IA V1/2_inact), IH also activates at more hyperpolarized voltages (low IH V1/2_act), represented by cells with exclusively yellow IA and light blue IH channels. In different sets of neurons, the activation/inactivation voltages for both currents are more depolarized, as depicted by the combination of either orange IA and blue IH channels for mid-range levels, or red IA and dark blue IH channels in cells with very depolarized levels of IA inactivation and IH activation. The different number of channels within individual cells in the schematic reflects the fact that the maximal conductance of IA and IH were not correlated in the population of tested neurons. B, Signaling based on intracellular calcium concentration shifts rebound properties. Reduced intracellular calcium availability, which causes an increase in cAMP in SN neurons, depolarizes the voltage dependences of IA and IH (illustrated in the shift from yellow to red, and from light blue to dark blue, respectively) and thus causes an increased response to inhibitory inputs, as shown by a decreased delay to first spike following the release of inhibition.
See this image and copyright information in PMC

Comment on

References

    1. Amendola J, Woodhouse A, Martin-Eauclaire MF, Goaillard JM. Ca2+/cAMP-sensitive covariation of IA and IH voltage dependences tunes rebound firing in dopaminergic neurons. J Neurosci. 2012;32:2166–2181. - PMC - PubMed
    1. Biel M, Wahl-Schott C, Michalakis S, Zong X. Hyperpolarization-activated cation channels: from genes to function. Physiol Rev. 2009;89:847–885. - PubMed
    1. Chan CS, Guzman JN, Ilijic E, Mercer JN, Rick C, Tkatch T, Meredith GE, Surmeier DJ. “Rejuvenation” protects neurons in mouse models of Parkinson's disease. Nature. 2007;447:1081–1086. - PubMed
    1. Liss B, Franz O, Sewing S, Bruns R, Neuhoff H, Roeper J. Tuning pacemaker frequency of individual dopaminergic neurons by Kv4.3L and KChip3.1 transcription. EMBO J. 2001;20:5715–5724. - PMC - PubMed
    1. MacLean JN, Zhang Y, Johnson BR, Harris-Warrick RM. Activity-independent homeostasis in rhythmically active neurons. Neuron. 2003;37:109–120. - PubMed

Publication types

LinkOut - more resources